Paranodin, a Glycoprotein of Neuronal Paranodal Membranes
نویسندگان
چکیده
منابع مشابه
Paranodin, a Glycoprotein of Neuronal Paranodal Membranes
Ranvier nodes are flanked by paranodal regions, at the level of which oligodendrocytes or Schwann cells interact closely with axons. Paranodes play a critical role in the physiological properties of myelinated nerve fibers. Paranodin, a prominent 180 kDa transmembrane neuronal glycoprotein, was purified and cloned from adult rat brain, and found to be highly concentrated in axonal membranes at ...
متن کاملThe paranodal complex of F3/contactin and caspr/paranodin traffics to the cell surface via a non-conventional pathway.
During myelination, membrane-specialized domains are generated by complex interactions between axon and glial cells. The cell adhesion molecules caspr/paranodin and F3/contactin play a crucial role in the generation of functional septate-like junctions at paranodes. We have previously demonstrated that association with the glycosylphosphatidylinositol-linked F3/contactin is required for the rec...
متن کاملThe Glycosylphosphatidyl Inositol-Anchored Adhesion Molecule F3/Contactin Is Required for Surface Transport of Paranodin/Contactin-Associated Protein (Caspr)
Paranodin/contactin-associated protein (caspr) is a transmembrane glycoprotein of the neurexin superfamily that is highly enriched in the paranodal regions of myelinated axons. We have investigated the role of its association with F3/contactin, a glycosylphosphatidyl inositol (GPI)-anchored neuronal adhesion molecule of the Ig superfamily. Paranodin was not expressed at the cell surface when tr...
متن کاملLiver sinusoid surface membranes and glycoprotein secretion.
toxin (1 pg/ml) or dibutyryl cyclic AMP (0.2m) to the culture medium in which the cells are propagated. The altered distribution of glycosylation in cells exposed to cholera toxin and dibutyryl cyclic AMP, which is less evident in cells exposed to conditions that restrict the expression of transformation, is also manifested in immune-precipitation reactions, in which cellular glycoproteins are ...
متن کاملTetraspanin protein CD9 is a novel paranodal component regulating paranodal junctional formation.
The axoglial paranodal junction is essential for the proper localization of ion channels around the node of Ranvier. The integrity of this junction is important for nerve conduction. Although recent studies have made significant progress in understanding the molecular composition of the paranodal junction, it is not known how these membrane components are distributed to the appropriate sites an...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Neuron
سال: 1997
ISSN: 0896-6273
DOI: 10.1016/s0896-6273(00)80942-3